加味五虎汤治疗小儿支原体感染急性喘息性支气管炎的疗效以及对Th1/Th2细胞因子的影响

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摘要 目的: 探讨加味五虎汤治疗小儿支原体感染急性喘息性支气管炎的疗效以及对辅助性T细胞（Helper T cells,Th）1/Th2细胞因子的影响。方法: 选择2020年3月至2023年3月我院收治的80例痰热闭肺型支原体感染急性喘息性支气管炎患儿,随机数字表法将患儿分为两组。对照组（40例）给予阿奇霉素抗感染辅以氨溴索、普米克令舒止咳平喘治疗1周,观察组（40例）在对照组基础上给予加味五虎汤治疗1周。比较两组疗效、中医证候积分、体温恢复正常时间、肺部啰音消失时间、咳嗽气喘消失时间、Th1细胞因子干扰素-γ（interferon-γ,IFN-γ）、肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）、Th2细胞因子白细胞介素（interleukin,IL）-4、IL-6水平及不良反应。结果: 观察组治疗有效率高于对照组,体温恢复正常时间、肺部啰音消失时间、咳嗽气喘消失时间短于对照组。两组治疗后血清IFN-γ、TNF-α、IL-4、IL-6水平较治疗前降低,观察组治疗后中医证候积分差值、血清IFN-γ、TNF-α、IL-4、IL-6水平低于对照组。结论: 与单纯西医治疗比较,加味五虎汤可改善痰热闭肺型支原体感染急性喘息性支气管炎患儿Th1/Th2细胞因子紊乱,提高临床疗效。

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	武进华
	贾林萍
	李静

关键词 ：加味五虎汤, 痰热闭肺型, 急性喘息性支气管炎, 免疫

Abstract：Objective To investigate the curative effect of modified Wuhu Decoction on acute asthmatic bronchitis infected with mycoplasma in children and its effect on Helper T cells (Th) 1/Th2 cytokines. Methods Prospective study. A total of 80 children with acute asthmatic bronchitis infected with phlegm-heat closed-lung mycoplasma treated in our hospital from March 2020 to March 2023 were selected and divided into two groups by random number table method. Control group (40 cases) was treated with azithromycin anti-infection combined with ambroxol and pramicol Ling Shu for 1 week, observation group (40 cases) was treated with supplemented Wuhu Decoction for 1 week on the basis of control group. Compared the therapeutic effect of the two groups, traditional Chinese medicine syndrome score, normal body temperature recovery time, disappearance time of lung crackles, disappearance time of cough and asthma, interferon-γ (IFN-γ), Tumor necrosis faction-α (TNF-α), Th2 cytokines interleukin (IL) -4, IL-6, adverse reactions. Results The effective rate of the observation group was higher than that of the control group, the time of body temperature returning to normal, the time of lung rales disappearing, the time of cough and asthma disappearing was shorter than that of the control group. The serum IFN-γ, TNF-α, IL-4 and IL-6 levels of the two groups after treatment were lower than those before treatment, and the serum difference of TCM syndrome score, IFN-γ, TNF-α, IL-4 and IL-6 levels of the observation group after treatment were lower than those of the control group (P<0.05). Conclusion Compared with Western medicine alone, adding Wuhu decoction can improve Th1/Th2 cytokine disorder in children with acute asthmatic bronchitis infected with phlegm-heat cloister-pulmonary mycoplasma and improve clinical efficacy.

Key words： Wuhu soup phlegm-heat closed lung type acute asthmatic bronchitis immune

收稿日期: 2023-11-05

中图分类号:

R725.6

基金资助:陕西省社会发展科技攻关项目“加味五虎汤联合西药治疗小儿支原体感染急性喘息性支气管炎的临床研究”（2020SF1025）

通讯作者: 李静,E-mail：wr816100@163.com

引用本文:

武进华, 贾林萍, 李静. 加味五虎汤治疗小儿支原体感染急性喘息性支气管炎的疗效以及对Th1/Th2细胞因子的影响[J]. 湖南师范大学学报(医学版), 2024, 21(2): 114-117. WU Jinhua, JIA Linping, LI Jing. Effect of Wuhu Decoction on acute asthmatic bronchitis caused by mycoplasma infection in children and its influence on Th1/Th2 cytokines. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(2): 114-117.

链接本文:

http://yxb.hunnu.edu.cn/CN/ 或 http://yxb.hunnu.edu.cn/CN/Y2024/V21/I2/114

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