Effect of Bushen Huoxue Jianpi Decoction in the treatment of polycystic ovary syndrome complicated with osteopenia and the impact on reproductive hormones,ovulation and bone metabolism
LI Wenjun1, LIU Wei1, LIN Zhuohui1, ZHU Liya2
1. The First Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China; 2. Gynecology Department, Guangzhou Women and Children's Medical Center,Guangzhou 510405, China
Abstract：Objective To observe the effect of treatment with Bushen Huoxue Jianpi Decoction on serum reproductive hormones,ovulation and bone metabolism in patients with PCOS and osteopenia. Methods A total of 106 patients with PCOS and osteopenia who were treated in the First Clinical Medical College,Guangzhou University of Traditional Chinese Medicine from May 2021 to April 2023,and met the inclusion and exclusion criteria were enrolled in this study. They were randomly assigned to the treatment group and the control group,with 53 patients in each group. Patients in the control group were treated with Diane-35 combined with olive oil. On this basis,patients in the treatment group were treated with Bushen Huoxue Jianpi Decoction. Reproductive hormones（FSH,LH and E2）,ovulation,menstruation and bone metabolism（BGP and PINP）in the two groups were observed. Clinical efficacy was evaluated. Results After treatment,ovarian volume,endometrial thickness,follicle count,duration and volume of menstruation,serum BGP and PINP in the two groups were significantly increased. Menstrual cycle and serum FSH,LH and E2 were significantly reduced. Meanwhile,ovarian volume,endometrial thickness,follicle count,duration and volume of menstruation,serum BGP and PINP in the treatment group were larger/longer/higher than those in the control group（P<0.05）. Menstrual cycle and serum FSH,LH and E2 in the treatment group were shorter/lower than those in the control group（P<0.05）. The total effective rate in the treatment group was significantly higher. Conclusion Treatment with Bushen Huoxue Jianpi Decoction can not only improve reproductive hormone levels and effectively correct ovulation and menstruation in patients with PCOS and osteopenia but also positively regulate bone metabolism,with significant effect.
李文珺, 刘薇, 林卓慧, 朱莉亚. 补肾活血健脾汤治疗多囊卵巢综合征伴骨量减少的效果及对生殖激素、排卵情况、骨代谢的影响[J]. 湖南师范大学学报(医学版), 2024, 21(1): 71-75.
LI Wenjun, LIU Wei, LIN Zhuohui, ZHU Liya. Effect of Bushen Huoxue Jianpi Decoction in the treatment of polycystic ovary syndrome complicated with osteopenia and the impact on reproductive hormones,ovulation and bone metabolism. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(1): 71-75.
2024, Vol. 21 
