Abstract：Objective To study the effect of Ruangan Jiangzhi capsule on vascular endothelial function and platelet function in patients with acute coronary syndrome. Methods A total of 120 patients with acute coronary syndrome admitted to Rugao Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Chinese Medicine from July 2021 to July 2022 were divided into the secondary prevention treatment group (60 cases) and combined the combined the Chinese medicine group (60 cases) by random number table method. The secondary prevention and treatment group was treated with standard secondary prevention drugs for coronary heart disease, and the combined Chinese medicine group was treated with Ruganjiangzhi capsule on the basis of the secondary prevention and treatment group, and both groups were treated for 6 months. The traditional Chinese medicine symptom score, cardiac function, serum vascular endothelial function index level, serum inflammatory factors, lipid metabolism index level, platelet function index, aspirin resistance and clopidogrel resistance were compared between the two groups, and the safety of the two groups was counted. Results After 6 months of treatment, compared with before treatment, the score of traditional Chinese medicine symptom, cardiac function and level of serum vascular endothelial function of the two groups were significantly improved, and the improvement degree of the combined Chinese medicine group was better than that of the secondary prevention treatment group . Before treatment and after 1 and 6 months of treatment, the levels of serum inflammatory factors and platelet function indexes in the two groups were significantly improved, and the improvement degree in the combined Chinese medicine group was better than that in the secondary prevention treatment group after 1 and 6 months of treatment . Before treatment and after 1, 3 and 6 months of treatment, the serum lipid metabolism indexes of the two groups were obviously improved, and the improvement degree of the combined Chinese medicine group after 1, 3 and 6 months of treatment was better than that of the secondary prevention treatment group . After 6 months of treatment, the aspirin resistance rate and clopidogrel resistance rate of the two groups increased compared with 1 month of treatment, and the combined Chinese medicine group was lower than the secondary prevention treatment group after 1 and 6 months of treatment . Conclusion Ruangan Jiangzhi Capsule could improve traditional Chinese medicine syndrome, cardiac function, vascular endothelial function and platelet function of patients with acute coronary syndrome, reduce the risk of inflammatory reaction, aspirin resistance and clopidogrel resistance, promote lipid metabolism, and at the same time, it would not increase the occurrence of adverse reactions, with good therapeutic effect.
李晓丽, 浦强, 吕军. 软肝降脂胶囊对急性冠脉综合征患者血管内皮功能及血小板功能的影响[J]. 湖南师范大学学报(医学版), 2023, 20(6): 73-78.
LI Xiaoli, PU Qiang, LV Jun. Effect of Ruangan Jiangzhi Capsule on Vascular Endothelial Function and Platelet Function in Patients with Acute Coronary Syndrome. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(6): 73-78.
2023, Vol. 20 
