Abstract：Objective To explore the effect of single-port thoracoscopic segmentectomy on lung function, serum trauma response and long-term metastasis in patients with early non-small cell lung cancer (NSCLC). Methods 200 patients with early NSCLC admitted to our hospital from April 2020 to September 2021 were divided into the control group (100 cases) and observation group (100 cases) by using a computer to randomly generate numbers. The control group received single-port thoracoscopic lobectomy while the observation group patients recceived single-port thoracoscopic segmentectomy. The surgical conditions of the two groups was compared, including lung function [forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and FEV1/FVC ratio], serum trauma response indicators [prostaglandin (PGE2), cortisol (Cor) and C-reactive protein (CRP) ] and tumor cell carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1) and squamous cell carcinoma antigen (SCC-Ag). The survival and long-term metastasis were tested by Kaplan-Meier curve, and the complications were compared. Results Compared with control group, the intraoperative blood loss in observation group was less and the surgical duration was shorter, but the number of lymph nodes dissection was not significantly different between the two groups. At 3 months after surgery, the lung function parameters FVC, FEV1 and FEV1/FVC in both groups were significantly decreased compared with those before surgery, but the decreases were relatively small in observation group, which had significant differences compared to control group. Serum levels of PGE2, Cor and CRP in the two groups at 1 month after surgery were significantly increased compared with those before surgery, but the increases in observation group were relatively small compared with those in control group. The levels of CEA, CYFRA21-1 and SCC-Ag in both groups was significantly reduced compared to before surgery, and the levels in observation group were lower than those in control group. At 2 years after surgery, metastasis was less in the two groups, and there was no significant difference in disease-free survival between the two groups. In addition, the complications revealed no obvious differences between the two groups. Conclusion Compared with lobectomy, single-port thoracoscopic segmentectomy in the treatment of NSCLC can better relieve the trauma response, maintain the lung function, and reduce the risk of tumor recurrence and metastasis.
奚雷, 侍烨, 崔伟明, 曹珲. 单孔胸腔镜肺段切除术治疗早期NSCLC患者肺功能及无瘤生存期的影响[J]. 湖南师范大学学报(医学版), 2023, 20(6): 108-112.
XI Lei, SHI Ye, CUI Weiming, CAO Hui. Effect of single-port thoracoscopic segmentectomy on lung function, and disease free survival in patients with early NSCLC. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(6): 108-112.
2023, Vol. 20 
