S-100B、LP-PLA2、circ_0021132在急性脑梗死中的表达及与复发的关系

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Abstract Objective To explore the expression of acid calcium binding protein (S-100B), lipoprotein-associated phospholipase A2(LP-PLA2), and circular RNA (circ_0021132) in acute cerebral infarction (ACI) and their relationship with recurrence. Methods From January 2019 to October 2020, 138 patients with ACI in our hospital were selected as the observation group, and 99 patients with healthy physical examination during the same period were selected as the control group. The blood levels of S-100B, LP-PLA2, and circ_0021132 were compared between the two groups. The observation group was followed up for 1 year to record the ACI recurrence rate. Cox regression method was used to analyze the related factors of ACI recurrence. The receiver operating characteristic curve (ROC) was used to analyze the predictive value of S-100B, LP-PLA2, circ_0021132 in recurrence. Results Serum S-100B [(1.21±0.20) μg/L vs (1.53±0.25) μg/L] and LP-PLA2 [(180.26±36.49) μg/L vs (238.72±49.75) μg/L] levels in the observation group decreased after treatment, and circ_0021132 [(1.61±0.18) vs (1.32±0.09)] levels increased. Serum S-100B and LP-PLA2 levels before and after treatment were higher than those in the control group, and circ_0021132 levels were lower than those in the control group (P<0.05). The expression of circ_0021132 increased after treatment of different types of cerebral infarction (P<0.05). circ_0021132 of patients with large atherosclerosis, cardiogenic embolization and small artery occlusion were lower than those with other clear and unknown etiology (P<0.05). After adjusting for cerebral infarct volume, smoking, carotid plaque, diabetes mellitus and hyperlipidemia by multivariate Cox regression equation, anti-platelet aggregation drugs, serum S-100B, LP-PLA2, and circ_0021132 levels after treatment remained were independent influencing factors of recurrence (P<0.05). The AUC of S-100B, LP-PLA2, and circ_0021132 combined to predict the recurrence of ACI was 0.897, and the PI value corresponding to the maximum Youden index was 0.17. With the increase of PI value (<0.1, 0.1~0.2, >0.2), the recurrence rate (0 vs 9.84% vs 32.69%) showed an increasing trend. Conclusion S-100B, LP-PLA2, and circ_0021132 expressed abnormally in ACI patients, and they are independent factors of ACI recurrence. Combined detection can provide an objective basis for clinical assessment of the risk of ACI recurrence.

Key words： S-100B LP-PLA2 circ_0021132 acute cerebral infarct

Received: 23 August 2023

PACS:

R743.3

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	LIU Jianxin
	WANG Gang
	LEI Guangwen

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LIU Jianxin,WANG Gang,LEI Guangwen. The expression of S-100B, LP-PLA2 and circ_0021132 in acute cerebral infarction and their relationship with recurrence[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(1): 119-124.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2024/V21/I1/119

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