外周血T细胞表达与硅肺患者肺功能状态、生存质量的关系

Abstract
Figure/Table
References
Related Citation (3)

Download: PDF (1780 KB) HTML (0 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the relationship between peripheral blood T-cell Profiles and pulmonary function and quality of life in silicosis patients. Methods 90 patients who underwent silicosis hospitalization in our hospital from September 2019-March 2021 were enrolled in the silicosis group. At the same time, 90 healthy people who underwent physical examination at the same time were selected as healthy controls. The differences of peripheral blood T cell expression between the two groups were compared, and the relationship between peripheral blood T cell expression and lung function status and quality of life in silicosis group was analyzed. Results Compared with control subjects, patients with silicosis had lower FEV1, FEV1/FVC, DLco, CD4⁺T cells and CD4⁺/CD8⁺, and higher RV and CD8⁺T cells. There were significant differences in FEV1, FEV1/FVC, RV and SGRQ symptom score, activity score and total score among stageⅠ, Ⅱ and Ⅲ silicosis patients. The percentage of CD8⁺ T cells was negatively correlated with DLco, and positively correlated with symptom score and activity score. The percentage of CD4⁺ T cells was negatively correlated with FEV1 and FEV1/FVC. Conclusion The percentage of CD8⁺ T cells in peripheral blood of silicosis patients is positively correlated with the abnormal degree of gas exchange, while the percentage of CD4⁺ T cells is negatively correlated with the abnormal degree of gas exchange.

Key words： silicosis peripheral blood T cells lung function quality of life

Received: 19 October 2022

R563.9

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	HONG Lun
	YANG Yimei

Cite this article:

HONG Lun,YANG Yimei. The relationship between the expression of T cells in peripheral blood and pulmonary function and quality of life in patients with silicosis[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(1): 101-104.

URL:

http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2023/V20/I1/101

[1] 吴娜, 杨晓丽, 赵倩, 等. 职业性硅肺与石棉肺临床特征对比研究[J]. 中国职业医学, 2018, 45(05) : 65-70.
[2] 周珊宇, 温贤忠, 李旭东, 等. 广东省2006—2016年新报告职业性尘肺病的流行病学特征[J]. 环境与职业医学, 2017, 34(12) : 1046-1053.
[3] De Oliveira HD, De Melo EBB, Silva JD, et al.Therapeutic effects of bone marrow-derived mononuclear cells from healthy or silicotic donors on recipient silicosis mice[J]. Stem Cell Res Ther, 2017, 8(1) : 259-270.
[4] 张添威, 郭微微, 王笑咪, 等. CD4~+T淋巴细胞ATP值在预测硅肺患者反复呼吸道感染中的价值[J]. 中华劳动卫生职业病杂志, 2020, 38(12) : 915-918.
[5] 曲良勇, 苑翠红, 钮建武, 等. 数字X射线摄影在尘肺筛查中的应用研究[J]. 中国辐射卫生, 2018, 27(5) : 87-90.
[6] 张继华, 张丽琼, 杨耀鹏, 等. 营养和心理干预联合肺康复训练操对慢阻肺患者的疗效[J]. 中华医学杂志, 2020, 100(2) : 110-115.
[7] 吴敏娟, 胥萍, 徐俊驰, 等. T细胞亚群与细胞因子在硅肺患者外周血中的表达及其意义[J]. 中国综合临床, 2017, 33(7) : 586-590.
[8] Han B, Yan B, Zhao N, et al.The influence of the functional capacity on subjective well-being and quality of life of patients with silicosis[J]. Aging Mental Health, 2013, 17(6) : 707-713.
[9] 胡清利, 孙强中. 免疫增强剂联合化疗治疗硅肺合并肺结核对免疫及肺功能的影响[J]. 临床肺科杂志, 2018, 23(3) : 399-401.
[10] Zhang Y, Zhou D, Wang F, et al.Bronchoalveolar Lavage Fluid microRNA-146a: A Biomarker of Disease Severity and Pulmonary Function in Patients With Silicosis[J]. J Occup Environ Med, 2016, 58(5) : e177-182.
[11] 马腾. 肺灌洗治疗硅肺合并慢性阻塞性肺疾病对患者肺功能及肺灌洗液中相关炎性因子水平的影响[J]. 中国临床医生杂志, 2018, 46(4) : 430-432.
[12] Jiang PR, Cao Z, Qiu ZL, et al.Plasma levels of TNF-α and MMP-9 in patients with silicosis[J]. Eur Rev Med Pharmacol Sci, 2015, 19(9) : 1716-1720.
[13] 柴晶晶, 朱华栋, 于学忠, 等. 慢性阻塞性肺疾病评估测试对COPD急性加重的有效性评估[J]. 中国急救医学, 2017, 37(2) : 158-162.
[14] Liu H, Yan B, Han B, et al.Assessment of respiration-related quality of life of Chinese patients with silicosis and its influencing factors using the St. George's Respiratory Questionnaire (SGRQ)[J]. J Clin Nurs, 2012, 21(11-12) : 1515-1523.
[15] 安海转, 贾晓霞, 樊凯, 等. CD8+调节性T细胞在疾病中的作用[J]. 中华风湿病学杂志, 2018, 22(3) : 214-216.