成人急性白血病血清MBL、MASP1和MASP2检测及其临床价值

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Abstract Objective To Detect the serum levels of MBL, MASP1 and MASP2 in adults with acute leukemia and study their clinical value Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of serum MBL, MASP1 and MASP2 in adult acute leukemia patients and normal healthy people, and receiver operating characteristic curve was used to analyze the sensitivity, specificity and accuracy of serum MBL, MASP1 and MASP2 in the diagnosis of adult acute leukemia. Results There was no significant difference in MBL between the leukemia group and the control group. The serum MASP1 level of the leukemia group was significantly lower than that of the control group, while the serum MASP2 level was significantly higher than that of the control group. People. The serum MBL level in patients with relapsed leukemia was significantly lower than that in patients with first-onset leukemia, and the level of MASP2 was significantly higher than that in patients with first-onset leukemia, while there was no significant difference in serum MASP1 between the two groups. Logistic regression analysis showed that serum levels of MBL, MASP1, MASP2 were associated with adult leukemia. The sensitivity, specificity and accuracy of MBL, MASP1 combined with MASP2 in the diagnosis of adult acute leukemia were 0.854, 0.810 and 0.664, respectively. Conclusion Serum MASP1 was significantly decreased while MASP2 was significantly increased in adult leukemia patients. The combined detection of MBL, MASP1 and MASP2 has a high diagnostic value for adult leukemia.

Key words： adult acute leukemia MBL MASP1 MASP2 clinical value

Received: 04 November 2022

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	Articles by authors
	WEI Yan
	LI Fang
	MA Zhuangzhuang
	ZHAO Jing
	ZHANG Haiyan
	LI Yanli

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WEI Yan,LI Fang,MA Zhuangzhuang等. Detection of Serum MBL, MASP1 and MASP2 in Adult Acute Leukemia and Its Clinical Value[J]. HuNan ShiFan DaXue XueBao(Yi Xue Ban), 2023, 20(1): 44-47.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2023/V20/I1/44

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