基于NHANES数据库多金属暴露和桥本甲状腺炎的相关性分析

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Abstract Objective This study aimed to expore the potential relationship between heavy metals in urine and Hashimoto's thyroiditis （HT）,providing a basis for the prevention and control of heavy metal exposure in the general population and in those with HT. Methods Data included 5 011 cases with both urinary heavy metals （cadmium,cobalt,barium,lead,uranium）concentration indexes and thyroid peroxidase antibody （TPOAb）or thyroglobulin antibody （TgAb）from the 2007-2012 National Health and Nutrition Examination Survey （NHANES）（2007-2012）. Logistic regression models were used to explore the relationship between heavy metals in urine and HT,and restricted cubic spline models were used to examine possible nonlinear associations and to use restricted cubic spline models to visualize the dose-response relationship between different concentrations of cadmium,cobalt,and barium and HT. Furthermore,subgroup analyses were performed for gender. Results The urinary cadmium concentration in HT patinets （0.27 μg/L）was significantly higher than that in the normal population （0.24 μg/L）,while the concentrations of the other heavy metals showed no statistical difference in HT distribution. Multifactorial logistic regression showed that the risk of HT increased by 23.7 % for each quartile increase in urinary cadmium （OR=1.237,95 % CI 1.083-1.414）,and by 9.7% for each quartile increase in urinary cobalt （OR=1.097,95 % CI 1.021-1.177）. Compared to the group with the lowest urinary barium concentration （Q1）,the group with the highest urinary barium concentration （Q4）had a 48 % reduction of the risk of HT （OR=0.520,95 % CI 0.295-0.916）. However,the results of restricted cubic spline regression showed no dose-response relationship between the three and the prevalence of HT. Conclusion Exposure to heavy metals （cadmium,cobalt,barium）is associated with HT. Cadmium and cobalt may serve as potential risk factors for HT,while barium may have a protective effect against the disease. Cadmium and cobalt may be more pronounced in women. This provides the evidence for the development of intervention and health promotion guidelines,raising awareness of heavy metal exposure.

Key words： Hashimoto's thyroiditis metal exposure national health and nutrition examination survey correlation analysis

Received: 11 January 2024

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	LI Mengran
	ZHANG Deyang
	ZHOU Yibin
	WANG Zhaoyi
	NI Lei

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LI Mengran,ZHANG Deyang,ZHOU Yibin等. Correlation Analysis of Metal Exposure and Hashimoto's Thyroiditis based on NHANES Database[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(4): 73-80.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2024/V21/I4/73

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