miR-124-3p联合SAA/hs-CRP比值对流感病毒性肺炎患儿预后的预测价值分析

Abstract
Figure/Table
References
Related Citation (4)

Download: PDF (2145 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To analyze the predictive value of microRNA-124-3p (miR-124-3p) combined with serum amyloid A (SAA) /high-sensitivity C-reactive protein (hs-CRP) ratio for the prognosis of children with influenza virus pneumonia, so as to provide a certain guidance for improving the clinical efficacy and prognosis of children. Methods The clinical data of 121 children with influenza virus pneumonia who were diagnosed and treated in Changzhou Maternal and Child Health Hospital from August 2022 to February 2024 were retrospectively analyzed. miR-124-3p and SAA/hs-CRP were measured at admission. According to the efficacy, the patients were divided into poor prognosis group (26 cases) and good prognosis group (95 cases). The factors affecting the prognosis of children were analyzed. The area under the receiver operating characteristic (ROC) curve (AUC) was used to predict the prognosis of children with miR-124-3p combined with SAA/hs-CRP. Results miR-124-3p and age in the poor prognosis group were lower than those in the good prognosis group, and SAA/hs-CRP, the proportion of severe cases, and the proportion of complications were higher than those in the good prognosis group, and the differences were statistically significant. Logistic regression analysis showed that miR-124-3p level (OR=0.213, 95%CI 0.104-0.435) was an independent protective factor affecting the prognosis of patients, and SAA/hs-CRP level (OR=4.158, 95%CI 1.632-10.590) and disease severity (OR=2.249, 95%CI 1.217-4.153) were independent risk factors. ROC curve showed that the sensitivity of miR-124-3p, SAA/hs-CRP and their combination to predict the prognosis of children was 73.10%, 76.90%, 84.60%, respectively, and the specificity was 73.70%, 71.60%, 90.50%, respectively. The AUC were 0.808, 0.794 and 0.930, respectively. Conclusion The clinical value of combined measurement of miR-124-3p and SAA/hs-CRP levels in predicting the prognosis of children with influenza virus pneumonia is better than that of single measurement.

Key words： influenza virus pneumonia in children microRNA-124-3p serum amyloid protein high-sensitivity C-reactive protein prediction of prognosis

Received: 26 April 2024

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Yayuan
	XING Fengjun

Cite this article:

LI Yayuan,XING Fengjun. The predictive value of miR-124-3p combined with SAA/hs-CRP ratio in the prognosis of children with influenza virus pneumonia[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(4): 29-33.

URL:

http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2024/V21/I4/29

[1] ZAREI F, JALLI R, IRANPOUR P, et al.Differentiation of Chest CT Findings Between Influenza Pneumonia and COVID-19: Interobserver Agreement Between Radiologists[J]. Acad Radiol, 2021, 28(10): 1331-1338.
[2] FU B, WU Z, HUANG L, et al.A comparison of demographic, epidemiological and clinical characteristics of hospital influenza-related viral pneumonia patients[J]. BMC Infect Dis, 2021, 21(1): 1002.
[3] HSING TY, LU CY, CHANG LY, et al.Clinical characteristics of influenza with or without Streptococcus pneumoniae co-infection in children[J]. J Formos Med Assoc, 2022, 121(5): 950-957.
[4] WANG QY, YUAN L, LIN JY, et al.Clinical characteristics of severe influenza virus-associated pneumonia complicated with bacterial infection in children: a retrospective analysis[J]. BMC Infect Dis, 2023, 23(1): 545.
[5] ZHOU J, LIN J, ZHAO Y, et al.Deregulated Expression of miR-483-3p Serves as a Diagnostic Biomarker in Severe Pneumonia Children with Respiratory Failure and Its Predictive Value for the Clinical Outcome of Patients[J]. Mol Biotechnol, 2022, 64(3): 311-319.
[6] ZHAO J, WANG Y, WANG D, et al.MiR-124-3p attenuates brain microvascular endothelial cell injury in vitro by promoting autophagy[J]. Histol Histopathol, 2022, 37(2): 159-168.
[7] 茹克亚木·色麦提, 迪拉拉·吐尔逊. miR-124-3p靶向TLR4抑制流感病毒性肺炎小鼠的炎症反应[J]. 生物技术通讯, 2020, 31(4): 399-403.
[8] 栾军, 袁杰, 张伟利. 中性粒细胞CD64表达指数降钙素原及血清淀粉样蛋白A/超敏C-反应蛋白比值在感染性肺炎患儿诊断中的应用价值[J]. 中国妇幼保健, 2022, 37(9): 1639-1642.
[9] 中华人民共和国国家健康委员会, 国家中医药局. 儿童社区获得性肺炎诊疗规范 (2019年版)[J]. 中华临床感染病杂志, 2019, 12(1): 6-13.
[10] 中华人民共和国国家卫生健康委员会, 国家中医药管理局. 流行性感冒诊疗方案 (2020年版)[J]. 中华临床感染病杂志, 2020, 13(6): 401-405+411.
[11] LUNA CM, BLANZACO D, NIEDERMAN MS, et al.Resolution of ventilator-associated pneumonia: prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcome[J]. Crit Care Med, 2003, 31(3): 676-682.
[12] 周明杨, 孙莹, 颜景礼, 等.2018—2020年某院PICU甲型流感病毒性肺炎临床和流行病学特征[J]. 中华医院感染学杂志, 2022, 32(2): 168-172.
[13] 王向阳, 吕敏. 血清肺表面活性蛋白D、肿瘤坏死因子-α表达与甲型流感病毒性肺炎患儿病情及预后的关系[J]. 中国临床医生杂志, 2022, 50(7): 858-861.
[14] 沈晓飞, 吴莉城, 李小红. 华盖散加减联合奥司他韦治疗小儿流感病毒性肺炎风寒闭肺证临床研究[J]. 新中医, 2021, 53(12): 27-31.
[15] 刘盼盼, 曾海珠, 张美兰, 等. 高强度间歇运动通过miR-124-3p/ERN1轴抑制吸烟相关的老年慢性阻塞性肺疾病炎症反应的机制[J]. 老年医学与保健, 2023, 29(5): 979-985.
[16] 孙雪莹, 邵宁, 赵志彬, 等. 血清miR-124-3p和TLR4联合检测对慢性阻塞性肺疾病合并感染的诊断价值[J]. 热带医学杂志, 2023, 23(3): 336-340+367.
[17] 张磊, 罗霄, 刘明靓, 等. 基于miR-124-3p/IL-6信号通路的槲皮素和表儿茶素协同调节炎症相关性结直肠癌研究[J]. 中草药, 2023, 54(5): 1471-1477.
[18] FAN F, LV J, YANG Q, et al.Clinical characteristics and serum inflammatory markers of community-acquired mycoplasma pneumonia in children[J]. Clin Respir J, 2023, 17(7): 607-617.
[19] 李东秀, 黄健. 血清sICAM-1和hs-CRP水平在儿童急性病毒性下呼吸道感染病情监测中的意义[J]. 检验医学, 2022, 37(3): 226-229.
[20] 李毅刚, 张毕明. SAA、PCT、hs-CRP、WBC和SAA/hs-CRP比值在儿童呼吸道病毒感染性疾病中的诊断价值[J]. 湖南师范大学学报 (医学版), 2022, 19(2): 67-70.
[21] 李重锦, 苏新星, 蒋丽君, 等. 重症肺炎患儿预后的危险因素及其列线图预测模型构建研究[J]. 实用心脑肺血管病杂志, 2021, 29(9): 47-52.
[22] 刘刚, 钱素云. 儿童重症病毒性肺炎的高危因素及治疗研究进展[J]. 北京医学, 2022, 44(6): 518-520+525.