The predictive value of miR-124-3p combined with SAA/hs-CRP ratio in the prognosis of children with influenza virus pneumonia
LI Yayuan1, XING Fengjun2
1. Department of Pediatrics, Changzhou Maternal and Child Health Hospital, Changzhou 213000, China; 2. Medical Department, Changzhou Children's Hospital, Changzhou 213000, China
AbstractObjective To analyze the predictive value of microRNA-124-3p (miR-124-3p) combined with serum amyloid A (SAA) /high-sensitivity C-reactive protein (hs-CRP) ratio for the prognosis of children with influenza virus pneumonia, so as to provide a certain guidance for improving the clinical efficacy and prognosis of children. Methods The clinical data of 121 children with influenza virus pneumonia who were diagnosed and treated in Changzhou Maternal and Child Health Hospital from August 2022 to February 2024 were retrospectively analyzed. miR-124-3p and SAA/hs-CRP were measured at admission. According to the efficacy, the patients were divided into poor prognosis group (26 cases) and good prognosis group (95 cases). The factors affecting the prognosis of children were analyzed. The area under the receiver operating characteristic (ROC) curve (AUC) was used to predict the prognosis of children with miR-124-3p combined with SAA/hs-CRP. Results miR-124-3p and age in the poor prognosis group were lower than those in the good prognosis group, and SAA/hs-CRP, the proportion of severe cases, and the proportion of complications were higher than those in the good prognosis group, and the differences were statistically significant. Logistic regression analysis showed that miR-124-3p level (OR=0.213, 95%CI 0.104-0.435) was an independent protective factor affecting the prognosis of patients, and SAA/hs-CRP level (OR=4.158, 95%CI 1.632-10.590) and disease severity (OR=2.249, 95%CI 1.217-4.153) were independent risk factors. ROC curve showed that the sensitivity of miR-124-3p, SAA/hs-CRP and their combination to predict the prognosis of children was 73.10%, 76.90%, 84.60%, respectively, and the specificity was 73.70%, 71.60%, 90.50%, respectively. The AUC were 0.808, 0.794 and 0.930, respectively. Conclusion The clinical value of combined measurement of miR-124-3p and SAA/hs-CRP levels in predicting the prognosis of children with influenza virus pneumonia is better than that of single measurement.
LI Yayuan,XING Fengjun. The predictive value of miR-124-3p combined with SAA/hs-CRP ratio in the prognosis of children with influenza virus pneumonia[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(4): 29-33.
2024, Vol. 21 
