半乳糖凝集素-9在儿童脓毒症合并急性呼吸窘迫综合征中的运用价值

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Abstract Objective To explore the clinical value of galectin -9(Gal-9) in differentiating acute respiratory distress syndrome (ARDS) from sepsis in children. Methods This study was a retrospective analysis. From March 2020 to May 2022, pediatric patients aged from 1 month to 18 years in PICU of the First Affiliated Hospital of Xi'an Jiaotong University were recruited as the research object. Patients were divided into sepsis group without ARDS (n=60) and sepsis group with ARDS (n=60). The levels of plasma Gal-9 and inflammatory molecules IL-6, TNF-α and IL-1β were analyzed by ELISA kit. Spearman correlation coefficient was used to analyze the correlation between plasma Gal-9 and inflammatory molecules. The diagnostic value of plasma Gal-9 in sepsis complicated with ARDS was analyzed by ROC curve. Patients were divided into two groups according to the Gal-9 critical value, and the survival curves of the two groups were compared. Results Compared with sepsis without ARDS, the levels of Gal-9, IL-6, TNF-α and IL-1β in sepsis with ARDS increased significantly. The level of plasma Gal-9 was positively correlated with the levels of TNF-α, IL-6 and IL-1β (r=0.391, 0.427 and 0.296, all P<0.05). When the critical value of Gal-9 was 265 pg/ml, the AUROC of Gal-9 was 0.804(95%CI 0.684-0.883, P<0.001). The sensitivity and specificity of plasma Gal-9 level in predicting sepsis with ARDS were 0.853 and 0.600, respectively, and the PPV, NPV and Youden indexes were 69.1%, 81.8% and 0.367, respectively. In patients with sepsis and sepsis complicated with ARDS, the 28-day survival rate was significantly lower when the Gal-9 level was ≥265 pg/mL than when the Gal-9 level was <265 pg/mL. Conclusions Gal-9 can be used as a biomarker for early prediction of ARDS in septic patients, and it is helpful to predict the survival rate.

Key words： galectin-9 sepsis acute respiratory distress syndrome children prognosis

Received: 03 June 2023

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R725

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	WANG Xiaoqiong
	YIN Xiaomei
	ZHANG Beibei
	FANG Xialing

Cite this article:

WANG Xiaoqiong,YIN Xiaomei,ZHANG Beibei等. The value of Galectin-9 in children with sepsis complicated with acute respiratory distress syndrome[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(3): 132-136.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2024/V21/I3/132

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