如意金黄散在阳证疮疡中的抗炎作用及对NLRP1/Caspase-1通路的影响

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Abstract Objective This study aims to explore the role of Ruyi Gold en Powder on inflammation and redness and swelling, heat and pain syndrome in skin and external diseases with Yang yndrome (SKDYS), and preliminarily reveal the influence of Ruyi Golden Powde on NLRP1/caspase-1 pathway in SKDYS. The findings in this study can provide strong clinical basis for following basic research. Methods A total of 105 patients with SKDYS admitted to the hospital from February 2021 to January 2023 were divided into control group receiving external application of fluoxetine (n=35) and observation group receiving external application of Ruyi Golden Powder (n=70) according the treatment method. Clinical efficacy of control and observation group was compared. Also, extent of redness and swelling, pain score, white blood cell level, neutrophil percentage, serum NLRP1, serum Caspase-1, and serum IL-1β and serum IL-18 of the two group before and after a 21-days of treatment were compared. Results Compared with before treatment, after 21 days of treatment both of two groups showed the significant decrease of the extent of redness and swelling, pain scores, white blood cell levels, neutrophil percentage, serum IL-1β, serum IL-18, serum NLRP1 and serum Caspase-1. After 21 days of treatment, compared with control group, observation group developed an increase in clinical efficacy, and the decreases in the extent of redness and swelling, pain score, white blood cell level, neutrophil percentage, and serum IL-1β, serum IL-18, serum NLRP1 and serum Caspase-1. Conclusion Ruyi Golden Powder effectively improved redness and selling and heat and pain of patients with SKDYS, and significantly inhibited the inflammatory response and NLRP1/Caspase-1 pathway in these patients. This study suggests the potential mechanism of Ruyi Golden Powder in treating SKDYS based on the NLRP1/Capase-1 pathway, providing a strong preliminary basis for following basic experiments.

Key words： skin and external diseases with Yang syndrome Ruyi Golden powder NLPR1 caspase-1

Received: 01 January 2024

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R26

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	GUO Wei
	XIANG Liping
	SONG Xiaoling

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GUO Wei,XIANG Liping,SONG Xiaoling. The anti-inflammatory role of Ruyi golden powder in skin and external diseases with Yang syndrome and its impact on NLRP1/Caspase-1 pathway[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(3): 63-68.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2024/V21/I3/63

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