急进短期高原暴露对中青年男性心脏的影响及可能机制

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Abstract Objective To observe the changes of myocardial enzymology, neuroendocrine and cardiac function in healthy young and middle-aged men before and after acute short-term plateau exposure; and to explore the effects and possible mechanisms of acute short-term plateau exposure on cardiac tissue cell function and neuroendocrine. Methods 50 healthy young and middle-aged male volunteers were randomly selected to collect physiological indices: heart rate (HR), respiratory rate (R), systolic blood pressure (SBP), diastolic blood pressure (DBP), and oxygen saturation (SaO2) at 7: 00 am 1 day before entering plateau (100 m above sea level), and 15 days after short-term exposure to plateau in an acute condition (3 000 m above sea level) in a fasting and seated position; cardiac enzymology and neuroendocrine function of cardiac tissues and cardiovascular function of cardiac tissues and cardiac cells were detected by using a fully automated biochemical analyzer. Neuroendocrine-related indexes: thyroid stimulating hormone (TSH), total thyroxine (TT4), free thyroxine (FT4), free tri-iodothyronine (FT3), total tri-iodothyronine (TT3), and cortisol (CORT); and color Doppler ultrasound diagnostic instrument was used to check the cardiac function indexes: right ventricular internal diameter (RV), right atrial internal diameter (RA), left ventricular diastolic internal diameter (LV), and left atrial internal diameter (LA). (LV), left atrial internal diameter (LA), aortic root internal diameter (AO), pulmonary artery internal diameter (PA), left ventricular long-axis shortening (LVFS), left ventricular ejection fraction (LVEF), stroke volume (SV), and left ventricular end-diastolic volume (LVEDV), comparing differences in indicators before and after acute short-term plateau exposure. Results Compared with before entering the plateau, the physiological parameter indicators of young and middle-aged men after 15 days of acute short-term plateau exposure: HR increased significantly, R increased, SBP increased, SaO2 decreased, DBP increased, and MAP increased, and the differences were statistically significant; cardiac enzyme indicators: LDH, CK-MB, CK, HBDH, IMA, Mb, cTnT, and hs-CRP were significantly elevated, and the differences were all statistically significant; neuroendocrine-related indices: TSH, TT4, FT4, FT3, TT3, and CORT were significantly elevated; and cardiac function indices: RV, RA, LV, LA, LVFS, LVEF, and SV, LVEDV were all decreased, and AO and PA were all increased, and the differences were all statistically significant. Conclusion Short-term acute plateau exposure can lead to acute plateau hypoxic myocardial injury, which is mainly manifested as oxidative stress, resulting in damage to myocardial cell membranes and outflow of relevant cardiac enzymes from myocardial cell membranes, which to a certain extent caused a decrease in cardiac compensatory capacity.

Key words： acute-access short-term plateau exposure low-pressure hypoxia young and middle-aged men

Received: 12 March 2024

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R541

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	PENG Zehong
	ZHU Xi
	WEN Jianglong
	ZHU Lili
	ZHU Wenzhuo
	LIU Chao
	CHENG Heng
	ZHANG Qi

Cite this article:

PENG Zehong,ZHU Xi,WEN Jianglong等. Effects and possible mechanisms of acute short-term plateau exposure on the heart in young and middle-aged men[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(3): 32-36.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2024/V21/I3/32

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