补肾活血健脾汤治疗多囊卵巢综合征伴骨量减少的效果及对生殖激素、排卵情况、骨代谢的影响

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Abstract Objective To observe the effect of treatment with Bushen Huoxue Jianpi Decoction on serum reproductive hormones,ovulation and bone metabolism in patients with PCOS and osteopenia. Methods A total of 106 patients with PCOS and osteopenia who were treated in the First Clinical Medical College,Guangzhou University of Traditional Chinese Medicine from May 2021 to April 2023,and met the inclusion and exclusion criteria were enrolled in this study. They were randomly assigned to the treatment group and the control group,with 53 patients in each group. Patients in the control group were treated with Diane-35 combined with olive oil. On this basis,patients in the treatment group were treated with Bushen Huoxue Jianpi Decoction. Reproductive hormones（FSH,LH and E₂）,ovulation,menstruation and bone metabolism（BGP and PINP）in the two groups were observed. Clinical efficacy was evaluated. Results After treatment,ovarian volume,endometrial thickness,follicle count,duration and volume of menstruation,serum BGP and PINP in the two groups were significantly increased. Menstrual cycle and serum FSH,LH and E₂were significantly reduced. Meanwhile,ovarian volume,endometrial thickness,follicle count,duration and volume of menstruation,serum BGP and PINP in the treatment group were larger/longer/higher than those in the control group（P<0.05）. Menstrual cycle and serum FSH,LH and E₂ in the treatment group were shorter/lower than those in the control group（P<0.05）. The total effective rate in the treatment group was significantly higher. Conclusion Treatment with Bushen Huoxue Jianpi Decoction can not only improve reproductive hormone levels and effectively correct ovulation and menstruation in patients with PCOS and osteopenia but also positively regulate bone metabolism,with significant effect.

Key words： Bushen Huoxue Jianpi decoction polycystic ovary syndrome osteopenia reproductive hormone ovulation bone metabolism

Received: 07 November 2023

PACS:

R711.75

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	LI Wenjun
	LIU Wei
	LIN Zhuohui
	ZHU Liya

Cite this article:

LI Wenjun,LIU Wei,LIN Zhuohui等. Effect of Bushen Huoxue Jianpi Decoction in the treatment of polycystic ovary syndrome complicated with osteopenia and the impact on reproductive hormones,ovulation and bone metabolism[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(1): 71-75.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2024/V21/I1/71

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