软肝降脂胶囊对急性冠脉综合征患者血管内皮功能及血小板功能的影响

Abstract
Figure/Table
References
Related Citation (5)

Download: PDF (2012 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To study the effect of Ruangan Jiangzhi capsule on vascular endothelial function and platelet function in patients with acute coronary syndrome. Methods A total of 120 patients with acute coronary syndrome admitted to Rugao Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Chinese Medicine from July 2021 to July 2022 were divided into the secondary prevention treatment group (60 cases) and combined the combined the Chinese medicine group (60 cases) by random number table method. The secondary prevention and treatment group was treated with standard secondary prevention drugs for coronary heart disease, and the combined Chinese medicine group was treated with Ruganjiangzhi capsule on the basis of the secondary prevention and treatment group, and both groups were treated for 6 months. The traditional Chinese medicine symptom score, cardiac function, serum vascular endothelial function index level, serum inflammatory factors, lipid metabolism index level, platelet function index, aspirin resistance and clopidogrel resistance were compared between the two groups, and the safety of the two groups was counted. Results After 6 months of treatment, compared with before treatment, the score of traditional Chinese medicine symptom, cardiac function and level of serum vascular endothelial function of the two groups were significantly improved, and the improvement degree of the combined Chinese medicine group was better than that of the secondary prevention treatment group . Before treatment and after 1 and 6 months of treatment, the levels of serum inflammatory factors and platelet function indexes in the two groups were significantly improved, and the improvement degree in the combined Chinese medicine group was better than that in the secondary prevention treatment group after 1 and 6 months of treatment . Before treatment and after 1, 3 and 6 months of treatment, the serum lipid metabolism indexes of the two groups were obviously improved, and the improvement degree of the combined Chinese medicine group after 1, 3 and 6 months of treatment was better than that of the secondary prevention treatment group . After 6 months of treatment, the aspirin resistance rate and clopidogrel resistance rate of the two groups increased compared with 1 month of treatment, and the combined Chinese medicine group was lower than the secondary prevention treatment group after 1 and 6 months of treatment . Conclusion Ruangan Jiangzhi Capsule could improve traditional Chinese medicine syndrome, cardiac function, vascular endothelial function and platelet function of patients with acute coronary syndrome, reduce the risk of inflammatory reaction, aspirin resistance and clopidogrel resistance, promote lipid metabolism, and at the same time, it would not increase the occurrence of adverse reactions, with good therapeutic effect.

Key words： Ruangan Jiangzhi capsule acute coronary syndrome Von Willebrand factor platelet α granule membrane glycoprotein lysosomal granular membrane glycoprotein

Received: 18 September 2023

PACS:

R541.4

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Xiaoli
	PU Qiang
	LV Jun

Cite this article:

LI Xiaoli,PU Qiang,LV Jun. Effect of Ruangan Jiangzhi Capsule on Vascular Endothelial Function and Platelet Function in Patients with Acute Coronary Syndrome[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(6): 73-78.

URL:

http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2023/V20/I6/73

[1] GALL E, LAFONT A, VARENNE O, et al.Balancing thrombosis and bleeding after out-of-hospital cardiac arrest related to acute coronary syndrome: A literature review[J]. Arch Cardiovasc Dis, 2021, 114(10): 667-679.
[2] 刘豪, 杨智勇. 阿司匹林联合替格瑞洛或氯吡格雷对急性冠状动脉综合征患者高尿酸血症发生率影响的对比研究[J]. 中国心血管病研究, 2020, 18(3): 256-259.
[3] 张辉, 冯禾, 王靖阳, 等. 中药汤剂联合标准治疗对急性冠脉综合征PCI术后影响的回顾性队列研究[J]. 天津中医药, 2022, 39(11): 1361-1366.
[4] 王计亮, 刘黎洁. 炙甘草汤联合替格瑞洛对急性冠脉综合征病人PCI术后血小板聚集功能和炎性因子水平的影响[J]. 中西医结合心脑血管病杂志, 2020, 18(12): 1929-1931.
[5] 葛媛, 王贺, 周亚滨, 等. 补阳还五汤加减对急性冠状动脉综合征 (气虚血瘀证) 患者的中医证候及炎症指标的影响[J]. 中国中医急症, 2021, 30(10): 1735-1738.
[6] 赵勇, 吕宜凤. 现代心血管病学[M]. 天津: 天津科学技术出版社, 2011: 74-76.
[7] 国家中医药管理局. 中医病证诊断疗效标准[M]. 南京: 南京大学出版社, 1994: 124-128.
[8] 中国高血压防治指南修订委员会. 中国高血压防治指南2010[J]. 中华心血管病杂志, 2011, 39(7): 579-616.
[9] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南 (2017年版)[J]. 中华糖尿病杂志, 2018, 10(1): 4-67.
[10] 徐东白, 韦琴英. 高脂血症防治指南[M]. 北京: 人民卫生出版社, 1999: 35-37.
[11] WHITTIER M, BAUTISTA S R, ARORA S, et al.Systemic Lupus Erythematosus and Antiphospholipid Antibody Syndrome as Risk Factors for Acute Coronary Syndrome in Young Patients: Analysis of the National Inpatient Sample[J]. J Clin Rheumatol, 2022, 28(3): 143-146.
[12] PEULTIER A C, VENETSANOS D, RASHID I, et al.European survey on acute coronary syndrome diagnosis and revascularisation treatment: Assessing differences in reported clinical practice with a focus on strategies for specific patient cases[J]. J Eval Clin Pract, 2020, 26(5): 1457-1466.
[13] 范鹏, 李毅, 王贺阳, 等. 质子泵抑制剂对服用阿司匹林联合氯吡格雷急性冠脉综合征患者净临床不良事件发生风险影响[J]. 临床军医杂志, 2019, 47(5): 463-465.
[14] 王冲冲, 邓天明, 王艳红. 温胆汤对急性冠脉综合征经皮冠状动脉介入术后患者脂蛋白磷脂酶A2的影响[J]. 广州中医药大学学报, 2022, 39(6): 1262-1267.
[15] 孔俊虹, 张琪, 陈弦, 等. 脉通饮对急性冠脉综合征PCI术后气虚血瘀证病人运动耐量及IL-6的影响[J]. 中西医结合心脑血管病杂志, 2023, 21(2): 315-320.
[16] 刘东升, 韩海莉, 李彬. 养心定悸胶囊对急性冠脉综合征合并室性早搏患者To-Tp间期及Tp-Te间期的影响[J]. 中国医药导报, 2020, 17(5): 67-70.
[17] 吴林林, 高占义, 魏月娟, 等. 益气活血方对急性冠脉综合征患者PCI术后血小板功能、血管内皮功能和运动耐力的影响[J]. 现代中西医结合杂志, 2021, 30(8): 825-829.
[18] 吕军, 薛刚. 软肝降脂胶囊治疗痰瘀痹阻型稳定性心绞痛合并颈动脉硬化斑块疗效观察[J]. 河北中医, 2020, 42(2): 214-217.
[19] 路陆, 王峰, 杨静, 等. 血府逐瘀汤联合心脉隆注射液对急性冠脉综合征患者PCI术后NT-proBNP、CRP及心功能的影响[J]. 现代中西医结合杂志, 2020, 29(8): 811-814.
[20] 唐旻忠, 王岩, 郭华庆, 等. 化痰祛瘀汤对非ST段抬高性急性冠脉综合征患者心室重构的影响[J]. 中国中医急症, 2019, 28(10): 1815-1818.