256例慢性肾脏病非透析患者的高敏肌钙蛋白I影响因素回顾性分析

Abstract
Figure/Table
References
Related Citation (1)

Download: PDF (1861 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the related influencing factors of hs-cTnI level in non-dialysis patients with chronic kidney disease, and to provide help for early screening and identifiCation of Cardiovascular event risk groups in patients with chronic kidney disease. Methods A single-center retrospective analysis was performed on 256 non-dialysis patients diagnosed with CKD who were hospitalized in a certain hospital of the People's Liberation Army from January 2018 to January 2019. Patients were divided into normal hs-cTnI group (n=183) and elevated hs-cTnI group (n=73) with hs-cTnI concentration of 0.034 ng/mL. General data and laboratory indicators (serum creatinine, myocardial enzyme, blood urea nitrogen, homocysteine, β2 microglobulin, hypersensitive C-reactive protein, parathyroid hormone, hs-cTnI) were compared between the two groups. Color Doppler ultrasound was performed for each patient, and relevant statistical methods were used to analyze the affecting factors of hs-cTnI in the patients. Results There were statistically significant differences in coronary heart disease history, systolic blood pressure, eGRF, Scr, BUN, β2 microglobulin, PTH, P, hemoglobin (Hb), left ventricular mass index (LVMI) and N terminal-pro brain natriuretic peptide (NT-proBNP) between the two groups. The results of multiple linear stepwise regression analysis showed that coronary heart disease history, Hb, NT-proBNP, LVMI, P and PTH were the influencing factors of hs-cTnI. The coronary heart disease history of non-dialysis patients with CKD showed a decrease in Hb. The increase of P, PTH, NT-pro BNP and LVMI Can lead to the increase of hs-cTn I level. Conclusion A history of coronary heart disease, anemia, elevated NT-proBNP, left ventricular hypertrophy, hyperparathyroidism, and hyperphosphatemia in non-dialysis CKD patients can cause hypersensitive troponin I to increase.

Key words： chronic kidney disease hypersensitive troponin I cardiovascular event

Received: 29 March 2023

PACS:

R692.5

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LIU Siyan
	WANG Xiangchuan

Cite this article:

LIU Siyan,WANG Xiangchuan. Retrospective analysis of the influential factors of hypersensitive troponin I in 256 non-dialysis patients with chronic kidney disease[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(4): 120-123.

URL:

http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2023/V20/I4/120

[1] deFilippi C, Seliger SL, Kelley W, et al. Interpreting Cardiac troponin results from high-sensitivity assays in chronic kidney disease without acute coronary syndrome[J]. Clin Chem, 2012, 58(9): 1342-1351.
[2] Astor BC, Hallan SI, Miller ER, et al.Glomerular filtration rate, albuminuria, and risk of Cardiovascular and all-Cause mortality in the US population[J]. Am J Epidemiol, 2008, 167(10): 1226-1234.
[3] Thygesen K, Alpert JS, Jaffe AS, et al.Third Universal Definition of Myocardial Infarction[J]. Circulation, 2012, 126(16): 2020-2035.
[4] 杨涛, 张永军, 郑亮, 等. 心电图新标准对高血压合并超重和肥胖人群左心室肥厚的诊断效能研究[J]. 中国全科医学, 2022, 25(36): 4502-4508.
[5] Yang CW, Li H, Thomas L, et al.Retrospective Cause analysis of troponin I elevation in non-Ca D patients[J]. Medicine, 2017, 96(37): e8027.
[6] 杨超, 王晋伟, 杨尧政, 等. 贫血及慢性肾脏病对糖尿病人群心脑血管事件发生与死亡的影响[J]. 北京大学学报 (医学版), 2018, 50(3): 495-500.
[7] 赵新菊. 慢性肾脏病贫血与左心室肥厚[J]. 中国血液净化, 2018, 17(7): 438-441.
[8] Schmid H, Schiffl H, Lederer SR.Erythropoiesis-stimulating agents, hypertension and left ventricular hypertrophy in the chronic kidney diseasepatient[J]. Curr Opin Nephrol Hypertens, 2011, 20(5): 465-470.
[9] Defilippi CR, Fink JC, Nass CM, et al.N-terminal pro-B-type natriuretic peptide for predicting coronary disease and left ventricular hypertrophy in asymptomatic CKD not requiring dialysis[J]. Am J Kidney Dis, 2005, 46(1): 35-44.
[10] 丁雪梅. 心肌肌钙蛋白及N-末端脑钠肽前体水平在老年慢性肾脏病中的变化及与预后的相关性[J]. 中国老年学杂志, 2014, 34(12): 3314-3316.
[11] NT-proBNP 临床应用中国专家共识小组. NT-proBNP 临床应用中国专家共识[J]. 中国心血管病研究, 2011, 9(6): 401-408.
[12] 耿旭, 马宾. BNP及NT-proBNP和心肌缺血缺氧关系的研究进展[J]. 医学综述, 2014, 20(8): 1374-1376.
[13] 王金艳, 吴国庆, 章念伟, 等. 早中期慢性肾脏病患者血清FGF-23水平与左心室肥厚关系的研究[J]. 江西医药, 2021, 56(8): 1125-1128.
[14] 谭若芸, 王笑云. 尿毒症毒素与心血管病变[J]. 中国血液净化, 2004, 3(2): 104-106.
[15] 杜春荔, 杨秉潜, 何春戈, 等. 终末期肾病患者甲状旁腺激素与肌钙蛋白水平的相关性研究[J]. 海南医学, 2016, 27(4): 534-536.