孕妇孕中期血清HIF-1α和CXCL6水平对子痫前期及妊娠结局的预测价值分析

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Abstract Objective To evaluate the predictive value of serum hypoxia inducible factor-1α (HIF-1α) and chemokine C-C motif ligand 6(CXCL6) levels in the second trimester of pregnancy for preeclampsia (PE) and pregnancy outcome. Methods A total of 140 PE patients (PE group) who delivered in northwest women's and children's hospital from January 2020 to January 2022 and had regular antenatal examination were included. They were further divided into mild group (66 cases) and severe group (74 cases) according to the severity of the disease.140 patients with simple hypertensive disorder complicating pregnancy (hypertensive disorder complicating pregnancy) were included. The control group consisted of 100 normal cases in the same period. The levels of serum HIF-1α and CXCL6 were detected by ELISA; the predictive value of serum HIF-1α, CXCL6 levels and their combination for PE and pregnancy outcome was evaluated by receiver operating characteristic (ROC) curve. Analysis of serum HIF-1α by Pearson method, CXCL6 level and correlation analysis with laboratory indicators; Logistic regression was used to analyze the influencing factors of PE pregnancy outcome. Results The levels of serum HIF-1α and CXCL6 in PE group were obviously higher than those in control group. Compared with the mild group, the diastolic blood pressure, systolic blood pressure, levels of TC, TG, LDL-C, IL-1β, IL-6, TNF-α, HIF-1α, CXCL6 in the severe group were obviously higher, while the level of HDL-C was obviously lower. ROC results showed that HIF-1α in serum, The level of CXCL6 and the AUC of the combined diagnosis of PE were 0.730, 0.751 and 0.858, respectively. The combined prediction of AUC was significantly higher than the two independent prediction of AUC (Z=3.367, 2.940, P<0.05). Compared with the good pregnancy outcome group, the diastolic blood pressure, systolic blood pressure, levels of TC, TG, LDL-C, IL-1β, IL-6, TNF-α, HIF-1α, CXCL6 with poor pregnancy outcome were obviously higher, while the level of HDL-C was obviously lower. HIF-1α in PE serum And the level of CXCL6 and IL-1βrespectively, IL-6, TNF-α There was a positive correlation (r=0.611, 0.639, 0.612, 0.569, P<0.05). The level of CXCL6 is different from IL-1β, IL-6, TNF-α There was a positive correlation (r=0.605, 0.584, 0.593, P<0.05). Multi-factor logistic analysis results show that IL-1β, TNF-α, HIF-1α, CXCL6 was an independent risk factor for poor pregnancy outcome in PE. ROC results showed that the AUC of serum HIF-1α, CXCL6 levels and their combination to predict the adverse pregnancy outcome of PE disease was 0.754, 0.775 and 0.854, respectively, the AUC of combined prediction was obviously higher than that of the two alone (Z=6.295, 6.912, P<0.05). Conclusion The levels of serum HIF-1α and CXCL6 in pregnant women with PE are increased, and are closely related to the severity of PE. They are expected to be predictive factors of PE and adverse pregnancy outcomes of pregnant women.

Key words： preeclampsia bad delivery outcome hypoxia inducible factor-1α chemokine C-C motif ligand 6 prediction

Received: 21 March 2023

PACS:

R714.24

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	CAO Xiangcuan
	XIE Dan
	BAI Qianrong

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CAO Xiangcuan,XIE Dan,BAI Qianrong. Evaluation of the predictive value of serum HIF-1α and CXCL6 levels in the second trimester of pregnancy for preeclampsia and pregnancy outcome[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(4): 96-101.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2023/V20/I4/96

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