更昔洛韦联合丙种球蛋白对腺病毒肺炎患儿免疫球蛋白、T淋巴细胞亚群及炎症因子的影响

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Abstract Objective To observe the effect of ganciclovir combined with gamma globulin on immunoglobulin, T lymphocyte subsets and inflammatory factors in children with adenovirus pneumonia. Methods 86 children with adenovirus pneumonia admitted to our hospital from January 2018 to May 2022 were selected as the research object, and were divided into two groups by random number table. The control group was treated with ganciclovir, and the observation group was treated with ganciclovir combined with gamma globulin for 2 consecutive weeks. The efficacy related indexes and adverse reaction rate of the two groups were compared, and the changes of cellular and humoral immune functions and inflammatory related factors were detected. Results The antipyretic time, cough stopping time, lung moist rale disappearance time nd hospitalization time in the observation group were shorter than those in the control group. Before treatment, there was no significant difference between the two groups in terms of cellular and humoral immune function indexes and inflammatory related factors. After 2 weeks of treatment, the levels of CD3⁺, CD4⁺, CD4⁺/CD8+, immunoglobulin A (IgA) and immunoglobulin G (IgG) in both groups were higher than those before treatment, and tumor necrosis factor α (TNF- α) 、 Interleukin-1(IL-1), interleukin-2(IL-2), Clara cell secretory protein (CCSP), CD8⁺, and immunoglobulin M (IgM) were lower than those before treatment. After 2 weeks of treatment, CD8⁺, IgM, and inflammatory related factors in the observation group were lower than those in the control group, while CD3⁺, CD4⁺, CD4⁺/CD8⁺, IgA, and IgG were higher than those in the control group. The cumulative adverse reactions in the observation group were 13.95% and 9.30% in the control group, with no statistical difference. Conclusion Ganciclovir combined with gamma globulin can improve the cellular and humoral immune function of children with adenovirus pneumonia, inhibit the expression of inflammation, reduce symptoms, and help children recover.

Key words： ganciclovir gamma globulin adenovirus pneumonia immunity

Received: 25 November 2022

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R72

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	PENG Juan
	YANG Suiyao

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PENG Juan,YANG Suiyao. Effect of ganciclovir combined with gamma globulin on immunoglobulin, T lymphocyte subsets and inflammatory factors in children with adenovirus pneumonia[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(4): 32-35.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2023/V20/I4/32

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