妊娠期糖尿病患者血清Sortilin水平与糖脂代谢、胰岛素抵抗的相关性及诊断价值分析

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Abstract Objective To investigate the diagnostic value of serum Sortilin level in gestational diabetes mellitus (GDM) and analyze its correlation with glucose and lipid metabolism and insulin resistance. Methods 911 pregnant women admitted to the obstetrical clinic of our hospital from February 2019 to February 2022 were selected as the study subjects, including 162 pregnant women with GDM (GDM group) and 749 pregnant women with normal glucose tolerance (control group). Serum Sortilin level were detected at gestation week 12, and week 20, 28 , glucose and lipid metabolism and insulin resistance were detected. The correlation between Sortilin and glucose and lipid metabolism, insulin resistance and the diagnostic value of Sortilin in GDM were analyzed. Results Age, pre-pregnancy body mass index, pregnancy body weight gain, serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo-B), fasting blood glucose (FPG), fasting insulin (FINS) level and insulin resistance index (HOMA-I) in GDM group were higher than that of control group. The serum Sortilin level of GDM group increased gradually from week 12 to week 28 of gestation, but had no significant change in the control group. The serum Sortilin level of GDM group at week 12, week 20 and week 28 of gestation was higher than that of the control group. Serum Sortilin level at gestation week 12, and week 20, 28 was positively correlated with TC, TG, LDL-C, APO-B, FPG, FINS, HOMA-IR. High pregnancy body weight gain, Sortilin at gestation week 20 and week 28 and HOMA-IR were risk factors for GDM. The area under the curve of Sortilin at gestation week 12 and week 20 in diagnosing GDM was 0.754(95%CI: 0.725-0.782), 0.807(95%CI: 0.779―0.832), with sensitivity of 77.78% and 80.86%, specificity of 69.83% and 79.97%. Conclusion Serum Sortilin level in GDM patients increases in the first trimester of pregnancy, which is related to glucose and lipid metabolism disorders and insulin resistance. Serum Sortilin level in the first trimester of pregnancy can be used as a predictive marker of GDM.

Key words： gestational diabetes mellitus glucolipid metabolism insulin resistance sortilin

Received: 28 February 2023

PACS:

R714.2

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	Articles by authors
	ZHU Yaofeng
	DU Chun
	SONG Huan
	HE Zezhen
	ZUO Lingyan
	GONG Ling
	ZHANG Yunyun

Cite this article:

ZHU Yaofeng,DU Chun,SONG Huan等. Correlation between serum Sortilin level with glucose and lipid metabolism and insulin resistance in patients with gestational diabetes mellitus and diagnostic value analysis[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(5): 95-98.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2023/V20/I5/95

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