盐酸氨溴索联合纤支镜肺泡灌洗治疗老年重症肺炎疗效及对氧化应激状态、炎症反应和肺泡氧合功能的影响

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Abstract Objective To explore the curative effect of ambroxol hydrochloride combined with bronchoscopic alveolar lavage in elderly patients with severe pneumonia (SP). Methods A total of 100 elderly patients with SP treated in the hospital were enrolled and randomly divided into control group and treatment group between September 2020 and December 2022, 50 cases in each group. The control group was treated with ambroxol hydrochloride, while treatment group was additionally treated with bronchoscopic alveolar lavage. A total of 50 patients given routine treatment during the same period were enrolled as routine group. The clinical curative effect after treatment, oxidative stress response, inflammatory response and alveolar oxygenation function before and after treatment, and adverse reactions during treatment in the three groups were compared. Results After treatment, total response rate of treatment group was higher than that of control group and routine group. After treatment, the related indexes of oxidative stress response, inflammatory response and alveolar oxygenation function in treatment group were better than those in control group and routine group. During treatment, there was no significant difference in adverse reactions among the three groups (P>0.05). Conclusion Compared with routine treatment and ambroxol hydrochloride alone, ambroxol hydrochloride combined with bronchoscopic alveolar lavage can enhance clinical curative effect, reduce oxidative stress response and inflammatory response, and improve alveolar oxygenation function in elderly patients with SP, with good safety.

Key words： elderly severe pneumonia ambroxol hydrochloride bronchoscopic alveolar lavage

Received: 21 March 2023

PACS:

R563.1

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	Articles by authors
	HUANG Jingying
	LU Chaoling
	QIN Shiyue
	TANG Dixiong
	ZHANG Yuancong

Cite this article:

HUANG Jingying,LU Chaoling,QIN Shiyue等. Curative effect of ambroxol hydrochloride combined with bronchoscopic alveolar lavage and its influences on oxidative stress, inflammatory response and alveolar oxygenation function in elderly patients with severe pneumonia[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(3): 58-60.

URL:

http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2023/V20/I3/58

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