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| Clinical observation on the efficacy of cinacalcet combined with Loratadine in treating skin pruritus in maintenance hemodialysis patients |
| JIANG Yafen, LIU Cangsang |
| Changsha Hospital Affiliated to Hunan Normal University/The Fourth Hospital of Changsha, Changsha 410006, China |
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Abstract Objective To observe the clinical efficacy of cinacalcet combined with loratadine in the treatment of skin pruritus in maintenance hemodialysis (MHD) patients. Methods 80 patients with regular hemodialysis and skin pruritus in our hospital's blood purification center from August 2020 to August 2021 were selected and randomly divided into a control group and an observation group, with 40 cases in each group. The control group was treated with loratadine, while the observation group was treated with cinacalcet combined with loratadine on the basis of the control group. After 3 months of continuous treatment, serum factors (BUN, Scr), clinical efficacy, visual analogue score (VAS), modified Duo itch score, Pittsburgh Sleep Quality Index questionnaire score (PSQI) and adverse reactions were compared between the two groups. Results Compared with before treatment, there was no significant difference in serum BUN and Scr between the two groups after treatment. The clinical efficacy of the observation group was significantly better than that of the control group, with a statistically significant difference. The VAS score, modified Duo itch score and PSQI score of patients in the observation group were significantly lower than those in the control group. Conclusion Cinacalcet combined with loratadine has a significant effect on MHD skin pruritus and can effectively relieve skin pruritus symptoms in MHD patients while improving their quality of life and sleep quality. It is worth promoting clinically.
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Received: 21 October 2022
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2023, Vol. 20 
