Abstract：Objective Research the PTPRO Gene promoter methylation and the expression of PTPRO gene mRNA in
colorectal cancer tissue and normal tissue adjacent to carcinoma,and to discuss their relationship in colorectal cancer. Methods
Methylation specific PCR (MSP) and RT-PCR were use to detected PTPRO gene promoter methylation status and mRNA’s
expression in 30 cases of colorectal cancer tissue and in normal tissue adjacent to carcinoma. Results The PTPRO gene promoter
methylation rate of colorectal cancer tissues is higher than normal tissue adjacent to carcinoma,the PTPRO gene mRNA’s expression of the methylation samples is obviously inhibitive. Conclusion The PTPRO gene promoter methylation plays an
important role in colorectal cancer, and it may be related to the development and prognosis of colorectal cancer
2015, Vol. 12 
