Value of ferritin and kidney injury molecule 1 in evaluating the condition and prognosis of lupus
ZHU Xiaohong1, JIANG Jiang2, GUO Gang2, DI ShiLin2
1. Hemodialysis Room, Qianjiang Central Hospital/Qianjiang Central Hospital Affiliated to Yangtze University, Qianjiang 433100; 2. Nephrology Department, Qianjiang Central Hospital/Qianjiang Central Hospital Affiliated to Yangtze University, Qianjiang 433100
Abstract： Objective To analyze the value of iron metabolism related indexes in evaluating the condition and prognosis of lupus nephritis (LN). Methods This was a single-center, cross-sectional, observational cohort study in our hospital. The study time was from January 2021 to June 2022, and the subjects were 101 patients with systemic lupus erythematosus (SLE) and 11 healthy controls. Baseline urinary ferritin level and kidney injury molecule 1(KIM-1) protein level were compared between SLE patients and control group, and correlated with clinical features and subsequent treatment response. Results Compared with patients with active non-nephritis (ANR), patients with active lupus nephritis (ALN) were younger, with higher female ratio, proteinuria, rSLEDAI and SLEDAI and lower hemoglobin (P<0.05). The urinary ferritin level in ALN group was significantly higher than that in other groups [ALN 8.96(4.15, 22.74) vs ANR 1.51(1.01, 3.14), inactive SLE(INA) 1.35(0.70, 3.10) and healthy controls 1.07(0.55, 1.42); H=43.57, P<0.05) ]. The urinary KIM-1 protein level in ALN group was significantly higher than that in ANR group and healthy controls [AlN 87.96(45.01, 185.90) vs ANR 16.48(4.91, 29.26), INA 9.62(3.13, 57.55) and healthy controls 9.78(3.13, 17.62); H=48.65, P<0.05) ]. Urinary ferritin and KIM-1 protein levels were positively correlated with proteinuria (correlation coefficient =0.385, 0.538, both P<0.05). Compared with the group with treatment response, the levels of serum inosine, urinary ferritin and KIM-1 protein in the group without treatment response increased significantly (P<0.05). The AUC values of urinary ferritin and KIM-1 protein in predicting the therapeutic response of ALN were 0.815(95%CI: 0.675-0.955) and 0.856(95%CI: 0.731-0.981), respectively. Conclusion Urinary ferritin and KIM-1 protein may be a promising candidate biomarker for predicting the therapeutic response of LN.
朱晓红, 姜江, 郭刚, 邸诗林. 铁蛋白和肾损伤分子1在评价狼疮病情和预后中的价值[J]. 湖南师范大学学报(医学版), 2024, 21(5): 60-65.
ZHU Xiaohong, JIANG Jiang, GUO Gang, DI ShiLin. Value of ferritin and kidney injury molecule 1 in evaluating the condition and prognosis of lupus. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(5): 60-65.
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2024, Vol. 21 
