香砂六君子贴敷联合昂丹司琼在预防和治疗mFOLFOX6方案化疗后不良反应的临床研究

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摘要 目的: 本研究旨在评估香砂六君子加减方贴敷神阙穴联合昂丹司琼在防治mFOLFOX6化疗方案引起的恶心、呕吐和食欲减退等不良反应,以期为中西医结合治疗胃癌化疗引起的副作用提供科学依据。方法: 本研究采用前瞻性随机对照试验设计,选取60例接受mFOLFOX6化疗方案的胃癌根治术后患者作为研究对象,并随机分配至对照组与治疗组。对照组患者在化疗第1、2、3天接受昂丹司琼静脉注射治疗,而治疗组在此基础上,从化疗第1天至第7天每天予香砂六君子加减方贴敷神阙穴,持续24 h。观察两个化疗周期中前三天的恶心、急性呕吐、食欲减退等情况,以及化疗第四天的迟发性呕吐情况和化疗前及两周期后的卡氏评分。结果: 治疗组在第1、2周期化疗后第1、2、3天的恶心程度的缓解有效率（0~Ⅰ度）均高于对照组,差异具有统计学意义。急性呕吐的治疗有效率同样高于对照组,差异显著。在迟发性呕吐方面,治疗组的发生率明显较低,差异有统计学意义。此外,治疗组在食欲减退方面的治疗有效率亦高于对照组,差异具有统计学意义。卡氏评分方面,治疗组与对照组均有所下降,但治疗组化疗前后差异无显著性,而对照组差异有显著性;两组间比较,治疗后的差异亦有显著性。结论: 香砂六君子贴敷联合昂丹司琼可以有效预防和治疗由mFOLFOX6化疗方案引起的恶心、呕吐和食欲减退等症状,同时能改善胃癌患者的生活质量。这一发现为中西医结合治疗化疗相关副作用提供了新的思路和策略。

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	宁智
	周戴
	戴新军
	王丹
	伍明辉
	彭越
	李翠英

关键词 ：化疗相关性呕吐, 胃癌, 昂丹司琼, 脐疗

Abstract：Objective This study was designed to evaluate the clinical efficacy and toxic side effect of Xiangsha Liujunzi paste applied to the Shenque acupoint in combination with Ondansetron in preventing and treating nausea, vomiting, and appetite loss caused by the mFOLFOX6 chemotherapy regimen. The goal of this study was to provide scientific evidence for the integration of traditional Chinese and Western medicine in treating vomiting induced by gastric cancer chemotherapy. Methods A prospective randomized controlled trial design was employed in this study. Sixty patients who underwent radical surgery for gastric cancer with the mFOLFOX6 chemotherapy regimen were selected as subjects and randomly assigned to the control group and the treatment group. The control group received Ondansetron (8mg Q12h intravenously) on days 1, 2, and 3 of chemotherapy, while the treatment group underwent additional Shenque acupoint application treatment daily from day 1 to day 7 of chemotherapy, lasting 24 hours. Observation indicators included the incidence of nausea, acute vomiting, appetite loss during the first three days of two chemotherapy cycles, delayed vomiting on day four of chemotherapy, and Karnofsky performance scores before and after two cycles. Results The treatment group showed a higher incidence of mild (grade 0-I) nausea on days 1, 2, and 3 after the first and second cycles of chemotherapy compared to the control group, with a statistically significant difference. The effectiveness of acute vomiting treatment was also significantly higher in the treatment group. In terms of the delayed vomiting, the incidence was significantly lower in the treatment group, with a statistically significant difference. Additionally, the treatment group demonstrated a higher effectiveness in treating appetite loss compared to the control group, with a statistically significant difference. Regarding Karnofsky performance scores, both groups experienced declines, but the difference before and after chemotherapy in the treatment group was not significant, whereas it was significant in the control group; the difference between the two groups after treatment was also significant. Conclusion The combination of Xiangsha Liujunzi paste application and Ondansetron can effectively prevent and treat negative symptoms of nausea, vomiting, and appetite loss induced by the mFOLFOX6 chemotherapy regimen, and it also improves the quality of life for patients with gastric cancer. These findings provide new insights and strategies for integrating traditional Chinese and Western medicine in treating chemotherapy-related side effect.

Key words： chemotherapy-induced nausea and vomiting gastric cancer ondansetron acupuncture therapy

收稿日期: 2024-05-29

基金资助:湖南省自然科学基金-医卫行业联合基金“基于PKM2及TGF-β信号通路探讨西黄丸调控骨微环境稳态抑制前列腺癌骨转移的机制研究”(2024JJ9570)

通讯作者: 李翠英E-mail：15576619549@163.com

引用本文:

宁智, 周戴, 戴新军, 王丹, 伍明辉, 彭越, 李翠英. 香砂六君子贴敷联合昂丹司琼在预防和治疗mFOLFOX6方案化疗后不良反应的临床研究[J]. 湖南师范大学学报(医学版), 2024, 21(4): 145-149. NING Zhi, ZHOU Dai, DAI Xingjun, WANG Dan, WU Minghui, PENG Yue, LI Cuiying. Clinical Study on the Prevention and Treatment of Negative Effect after mFOLFOX6 Chemotherapy Protocol using a Combination of Xiangsha Liujunzi Paste and Ondansetron. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(4): 145-149.

链接本文:

http://yxb.hunnu.edu.cn/CN/ 或 http://yxb.hunnu.edu.cn/CN/Y2024/V21/I4/145

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