miR-124-3p联合SAA/hs-CRP比值对流感病毒性肺炎患儿预后的预测价值分析

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摘要 目的: 分析微小RNA-124-3p（microRNA-124-3p,miR-124-3p）联合血清淀粉样蛋白A（serum amyloid protein,SAA）/超敏C反应蛋白（high-sensitivity C-reactive protein,hs-CRP）比值对流感病毒性肺炎患儿预后的预测价值,为临床提升患儿疗效、改善预后提供一定的指导。方法: 回顾性分析2022年8月―2024年2月间在常州市妇幼保健院进行诊疗的121例儿童流感病毒性肺炎患儿的临床相关资料。患儿入院时均行miR-124-3p、SAA及hs-CRP测定。根据疗效分为预后不良组（26例）和预后良好组（95例）。分析影响患儿预后的因素,使用受试者工作特征（ROC）曲线下面积（AUC）分析miR-124-3p联合SAA/hs-CRP比值的预后价值。结果: 预后不良组miR-124-3p、年龄低于预后良好组,SAA/hs-CRP比值、重症占比、合并并发症占比均高于预后良好组,差异有统计学意义。Logistic回归分析显示,miR-124-3p水平（OR=0.213,95%CI：0.104~0.435）是患者预后独立保护因素,SAA/hs-CRP水平（OR=4.158,95%CI：1.632~10.590）、病情严重程度（OR=2.249,95%CI：1.217~4.153）是独立危险因素。ROC曲线显示,miR-124-3p、SAA/hs-CRP比值及二者联合预测患儿预后的敏感度分别为73.10%、76.90%、84.60%,特异性分别为73.70%、71.60%、90.50%,AUC分别为0.808、0.794、0.930。结论: 临床联合测定miR-124-3p与SAA/hs-CRP比值预测流感病毒性肺炎患儿预后的价值优于单一预测价值。

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	李亚媛
	邢凤军

关键词 ：流感病毒性肺炎儿童, 微小RNA-124-3p, 血清淀粉样蛋白, 超敏C反应蛋白, 预后预测

Abstract：Objective To analyze the predictive value of microRNA-124-3p (miR-124-3p) combined with serum amyloid A (SAA) /high-sensitivity C-reactive protein (hs-CRP) ratio for the prognosis of children with influenza virus pneumonia, so as to provide a certain guidance for improving the clinical efficacy and prognosis of children. Methods The clinical data of 121 children with influenza virus pneumonia who were diagnosed and treated in Changzhou Maternal and Child Health Hospital from August 2022 to February 2024 were retrospectively analyzed. miR-124-3p and SAA/hs-CRP were measured at admission. According to the efficacy, the patients were divided into poor prognosis group (26 cases) and good prognosis group (95 cases). The factors affecting the prognosis of children were analyzed. The area under the receiver operating characteristic (ROC) curve (AUC) was used to predict the prognosis of children with miR-124-3p combined with SAA/hs-CRP. Results miR-124-3p and age in the poor prognosis group were lower than those in the good prognosis group, and SAA/hs-CRP, the proportion of severe cases, and the proportion of complications were higher than those in the good prognosis group, and the differences were statistically significant. Logistic regression analysis showed that miR-124-3p level (OR=0.213, 95%CI 0.104-0.435) was an independent protective factor affecting the prognosis of patients, and SAA/hs-CRP level (OR=4.158, 95%CI 1.632-10.590) and disease severity (OR=2.249, 95%CI 1.217-4.153) were independent risk factors. ROC curve showed that the sensitivity of miR-124-3p, SAA/hs-CRP and their combination to predict the prognosis of children was 73.10%, 76.90%, 84.60%, respectively, and the specificity was 73.70%, 71.60%, 90.50%, respectively. The AUC were 0.808, 0.794 and 0.930, respectively. Conclusion The clinical value of combined measurement of miR-124-3p and SAA/hs-CRP levels in predicting the prognosis of children with influenza virus pneumonia is better than that of single measurement.

Key words： influenza virus pneumonia in children microRNA-124-3p serum amyloid protein high-sensitivity C-reactive protein prediction of prognosis

收稿日期: 2024-04-26

基金资助:江苏省基础研究计划青年基金项目（BK20210097）

通讯作者: 邢凤军,E-mail：18862808352@163.com

引用本文:

李亚媛, 邢凤军. miR-124-3p联合SAA/hs-CRP比值对流感病毒性肺炎患儿预后的预测价值分析[J]. 湖南师范大学学报(医学版), 2024, 21(4): 29-33. LI Yayuan, XING Fengjun. The predictive value of miR-124-3p combined with SAA/hs-CRP ratio in the prognosis of children with influenza virus pneumonia. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(4): 29-33.

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http://yxb.hunnu.edu.cn/CN/ 或 http://yxb.hunnu.edu.cn/CN/Y2024/V21/I4/29

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