Retrospective analysis of the influential factors of hypersensitive troponin I in 256 non-dialysis patients with chronic kidney disease
LIU Siyan1, WANG Xiangchuan2
1. School of Medicine, Hunan Normal University, Changsha 410013, China; 2. 921st Hospital of the Joint Service and Security Force of the Chinese People's Liberation Army, Changsha 410022, China
Abstract：Objective To explore the related influencing factors of hs-cTnI level in non-dialysis patients with chronic kidney disease, and to provide help for early screening and identifiCation of Cardiovascular event risk groups in patients with chronic kidney disease. Methods A single-center retrospective analysis was performed on 256 non-dialysis patients diagnosed with CKD who were hospitalized in a certain hospital of the People's Liberation Army from January 2018 to January 2019. Patients were divided into normal hs-cTnI group (n=183) and elevated hs-cTnI group (n=73) with hs-cTnI concentration of 0.034 ng/mL. General data and laboratory indicators (serum creatinine, myocardial enzyme, blood urea nitrogen, homocysteine, β2 microglobulin, hypersensitive C-reactive protein, parathyroid hormone, hs-cTnI) were compared between the two groups. Color Doppler ultrasound was performed for each patient, and relevant statistical methods were used to analyze the affecting factors of hs-cTnI in the patients. Results There were statistically significant differences in coronary heart disease history, systolic blood pressure, eGRF, Scr, BUN, β2 microglobulin, PTH, P, hemoglobin (Hb), left ventricular mass index (LVMI) and N terminal-pro brain natriuretic peptide (NT-proBNP) between the two groups. The results of multiple linear stepwise regression analysis showed that coronary heart disease history, Hb, NT-proBNP, LVMI, P and PTH were the influencing factors of hs-cTnI. The coronary heart disease history of non-dialysis patients with CKD showed a decrease in Hb. The increase of P, PTH, NT-pro BNP and LVMI Can lead to the increase of hs-cTn I level. Conclusion A history of coronary heart disease, anemia, elevated NT-proBNP, left ventricular hypertrophy, hyperparathyroidism, and hyperphosphatemia in non-dialysis CKD patients can cause hypersensitive troponin I to increase.
刘思言, 王湘川. 256例慢性肾脏病非透析患者的高敏肌钙蛋白I影响因素回顾性分析[J]. 湖南师范大学学报(医学版), 2023, 20(4): 120-123.
LIU Siyan, WANG Xiangchuan. Retrospective analysis of the influential factors of hypersensitive troponin I in 256 non-dialysis patients with chronic kidney disease. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(4): 120-123.
2023, Vol. 20 
