中国中老年人胰岛素抵抗代谢评分与新发脑卒中相关性研究

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摘要 目的：探讨中老年人胰岛素抵抗代谢评分（METS-IR）与新发脑卒中之间的关系。方法：数据来源于2011年至2018年的中国健康与养老追踪调查（CHARLS）的数据。建立回归模型探究METS-IR与新发脑卒中之间的关联,同时采用限制立方样条模型来检查可能的非线性关联,并且采用亚组分析探究可能的潜在的调节变量。结果：研究共纳入6706名研究对象,其中新发脑卒中381人,回归模型结果发现METS-IR每上升一个四分位数,新发生脑卒中的患病风险增加67.3%（OR=1.673,95%CI：1.440~1.944）。使用限制性三次样条回归分析显示METS-IR与新发脑卒中患病率之间存在线性的相关关系,分层分析结果发现METS-IR与新发脑卒中的关系在不同亚组中一致。结论：METS-IR与新发脑卒中患病率密切相关,高METS-IR的人群需要更加警惕发生脑卒中的风险。

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关键词 ：胰岛素抵抗代谢评分, 脑卒中, 相关性研究, 中国健康与养老追踪调查

Abstract：Objective Stroke is a major cause of cardiovascular mortality and may have a correlative relationship with insulin resistance. To investigate the relationship between the metabolic score for insulin resistance (METS-IR) and new-onset stroke in middle-aged and elderly people based on a large cohort study. Methods Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS) in 2011 and 2018. Regression models were developed to explore the association between METS-IR and new-onset stroke, while restricted cubic spline models were used to examine possible nonlinear associations and subgroup analyses were used to explore possible potential moderating variables. Results A total of 6706 study subjects were included in the study, including 381 with new-onset stroke. The regression model results found a 67.3% increase in the risk of new-onset stroke for each quartile increase in the METS-IR (OR=1.673, 95% CI: 1.440-1.944). A linear relationship between the METS-IR and the prevalence of new-onset stroke was shown using restricted three-sample regression analysis, and stratified analysis revealed that the relationship between METS-IR and new-onset stroke was consistent across subgroups. Conclusion The METS-IR is strongly associated with the prevalence of new-onset stroke, and people with high METS-IR need to be more alert to the risk of stroke.

Key words： METS-IR stroke association study CHARLS

收稿日期: 2023-07-30

中图分类号:

R743.3

基金资助:辽宁省教育厅2020年度科学研究经费资助项目（FWZR2020004）

通讯作者: 于洋,E-mail：yuyang@cmu1h.com

引用本文:

沙鸥, 于洋. 中国中老年人胰岛素抵抗代谢评分与新发脑卒中相关性研究[J]. 湖南师范大学学报(医学版), 2023, 20(5): 70-74. SHA Ou, YU Yang. Association study between Metabolic Insulin Resistance Score and New-Onset Stroke in middle-aged and elderly Chinese population. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(5): 70-74.

链接本文:

http://yxb.hunnu.edu.cn/CN/ 或 http://yxb.hunnu.edu.cn/CN/Y2023/V20/I5/70

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