脑深部电刺激联合美多巴对帕金森病患者UPDRS、PDQ-39及MoCA评分的分析

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摘要 目的：分析脑深部电刺激（deep brain stimulation,DBS）联合美多巴对帕金森病（Parkison's disease,PD）患者统一帕金森病评定量表（unified Parkimson's disease rating seale,UPDRS）、39项帕金森病生存质量调查问卷（the 39-item Parkinson's disease questionnaire,PDQ-39）及蒙特利尔认知评估量表（Montreal cognitive assessment scale,MoCA）评分的影响。方法：选取我院2020年1月―2022年6月62例PD患者,随机数字表法分为两组。对照组31例予以美多巴治疗,实验组31例予以DBS联合美多巴治疗。比较两组临床疗效、治疗前后UPDRS、PDQ-39及MoCA评分、成本效益比。结果：实验组治疗总有效率为90.32%高于对照组67.74%;实验组治疗后UPDRS-Ⅰ评分、UPDRS-Ⅱ评分和UPDRS-Ⅲ评分均低于对照组;实验组治疗后PDQ-39各维度评分及总分均低于对照组;实验组治疗后MoCA各维度评分及总分均高于对照组;实验组成本效益比高于对照组。结论：DBS联合美多巴治疗PD的临床疗效显著,可以有效提高患者的生存质量,促进认知功能恢复,但其成本效益较高。

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	刘海峰
	兰杰
	樊华声
	吴静
	王智龙
	魏风

关键词 ：帕金森病, 脑深部电刺激, 美多巴, 统一帕金森病评定量表, 39项帕金森病生存质量调查问卷, 蒙特利尔认知评估量表

Abstract：Objective To analyze the effects of deep brain stimulation (DBS) combined with madopar on patients with Parkinson's disease (PD). Methods A total of 62 patients with PD in the hospital were enrolled between January 2020 and June 2022. They were randomly divided into control group (madopar) and observation group (DBS combined with madopar), 31 cases in each group. The clinical curative effect, scores of unified Parkimson's disease rating seale, the 39-item Parkinson's Disease Questionnaire and Montreal cognitive assessment scale, and cost effectiveness ratio were compared. Results The total effective rate of the observation group was 90.32% higher than that of the control group 67.74%. After treatment, scores of UPDRS-I, UPDRS-II and UPDRS-III in observation group were lower than those in control group. After treatment, the scores and total scores of PDQ-39 in all dimensions in the observation group were lower than those in the control group, and the scores and total scores of MoCA in all dimensions were higher than those in the control group. The cost effectiveness ratio of the experimental group is higher than that of the control group. Conclusion The clinical curative effect of DBS combined with madopar is significant on PD, which can effectively improve quality of life and promote the recovery of cognitive function.

Key words： Parkinson's disease deep brain stimulation madopar unified Parkinson's disease rating scale the 39-item Parkinson's disease questionnaire Montreal cognitive assessment scale

收稿日期: 2023-02-06

中图分类号:

R742.5

基金资助:广西壮族自治区卫生健康委员会自筹科研课题（Z20201204）

通讯作者: 魏风,E-mail：1320333805@qq.com

引用本文:

刘海峰, 兰杰, 樊华声, 吴静, 王智龙, 魏风. 脑深部电刺激联合美多巴对帕金森病患者UPDRS、PDQ-39及MoCA评分的分析[J]. 湖南师范大学学报(医学版), 2023, 20(2): 46-50. LIU Haifeng, LAN Jie, FAN Huasheng, WU Jing, WANG Zhilong, WEI Feng. Effects of deep brain stimulation combined with madopar on scores of UPDRS, PDQ-39 and MoCA in patients with Parkinson's disease. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(2): 46-50.

链接本文:

http://yxb.hunnu.edu.cn/CN/ 或 http://yxb.hunnu.edu.cn/CN/Y2023/V20/I2/46

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