Abstract：Autophagy is a highly evolutionarily conserved programmed degradation process that is essential for maintaining organism health. As a fundamental cellular metabolic process, autophagy is involved in regulating biological activities such as cell stress adaptation, stem cell differentiation, immunoregulation, learning and memory. However, the dysfunction of autophagy directly leads to various diseases including immune inflammatory disorders, neurodegenerative diseases and tumorigenesis. Uncovering the regulatory mechanism of autophagy help provide effective drug targets and therapeutic interventions for autophagy-related diseases. Previous studies have shown that many transcription factors such as FOXO, p53, and TFEB strictly and specifically regulate the process of autophagy when cells are exposed to different extracellular stress, thus enhancing or suppressing related diseases progression. This review presents an overview of the molecular mechanisms of FOXO, p53 and TFEB in regulating autophagy and elucidates their regulatory roles in diseases including tumors, in order to provide scientific and reeasonable clues for further unravelling novel functions of other transcription factors in autophagy.
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